NOVEL FOLD AND PUTATIVE RECEPTOR-BINDING SITE OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR

被引：193
作者：
DIEDERICHS, K
BOONE, T
KARPLUS, PA
机构：
[1] CORNELL UNIV,BIOCHEM MOLEC & CELL BIOL LAB,ITHACA,NY 14853
[2] AMGEN INC,THOUSAND OAKS,CA 91320
来源：
SCIENCE | 1991年 / 254卷 / 5039期
关键词：
D O I：
10.1126/science.1837174
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates the development of and the cytotoxic activity of white blood cells. Recombinant human GM-CSF has proven useful in the treatment of blood disorders. The structure of GM-CSF, which was determined at 2.4 angstrom resolution by x-ray crystallography, has a novel fold combining a two-stranded antiparallel-beta-sheet with an open bundle of four a helices. Residues implicated in receptor recognition, which are distant in the primary sequence, are on adjacent alpha-helices in the folded protein. A working model for the receptor binding site is presented.
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页码：1779 / 1782
页数：4
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