Brown adipose tissue Recent insights into development, metabolic function and therapeutic potential

被引：129

作者：

Townsend, Kristy L. ^{[1
,2
]}

Tseng, Yu-Hua ^{[1
,2
,3
]}

机构：

[1] Joslin Diabet Ctr, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 USA

来源：

ADIPOCYTE | 2012年 / 1卷 / 01期

关键词：

brown adipose tissue; thermogenesis; UCP1; mitochondria; BATokine; browning; adipogenesis;

D O I：

10.4161/adip.18951

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is currently a global pandemic and is associated with increased mortality and co-morbidities including many metabolic diseases. Obesity is characterized by an increase in adipose mass due to increased energy intake, decreased energy expenditure, or both. While white adipose tissue is specialized for energy storage, brown adipose tissue has a high concentration of mitochondria and uniquely expresses uncoupling protein 1, enabling it to be specialized for energy expenditure and thermogenesis. Although brown fat was once considered only necessary in babies, recent morphological and imaging studies have provided evidence that, contrary to prior belief, this tissue is present and active in adult humans. In recent years, the topic of brown adipose tissue has been reinvigorated with many new studies regarding brown adipose tissue differentiation, function and therapeutic promise. This review summarizes the recent advances, discusses the emerging questions and offers perspective on the potential therapeutic applications targeting this tissue.

引用

页码：13 / 24

页数：12

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