SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF 3-(5- SUBSTITUTED PHENYL- 1, 3, 4 - OXADIAZOL- 2 - YL) PYRIDINES

被引：1

作者：

Parthiban, P. ^{[1
]}

Alagarsamy, V ^{[1
]}

Jacob, Jemi ^{[2
]}

Singh, Hanish J. C. ^{[1
]}

Kumar, Sathesh S. ^{[1
]}

Bose, Subhash Chandra ^{[1
]}

机构：

[1] MNR Coll Pharm, Sangareddy, AP, India

[2] Delhi Inst Pharmaceut Sci & Res, New Delhi, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2010年 / 1卷 / 08期

关键词：

Oxadiazole or Pyridine Derivatives; Phosphorous Oxychloride; Antibacterial Activity; Antifungal Activity;

D O I：

10.13040/IJPSR.0975-8232.1(8).109-04

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of 3- (5- substituted phenyl- 1, 3, 4- Oxadiazol- 2- yl) pyridines was designed, synthesized and characterized for evaluation of potential antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella species and antifungal activity against Candida albicans. Structure-activity relationship led to the conculsion that compound IVb, and IVe exhibited good antibacterial activity against Bacillus subtilis and Staphylococcus aureus and comparatively poor activity against Klbesiella species and Escherichia coli. Compound C exhibited antibacterial activity against Staphylococcus aureus and very poor activity against rest of organism. Compounds IVa, IVb and IVe showed poor antifungal activity against Candida albicans and compounds IVc and IVd showed no significant antifungal activity. The interesting antimicrobial profile of compound IVb and IVe led us to select this derivative for further development. Present research our expected compounds were given below.

引用

页码：109 / 114

页数：6

共 24 条

[1] Synthesis and in vitro microbiological evaluation of imidazo(4,5-b)pyridinylethoxypiperidones [J].