ETHANOL NEUROTOXICITY IN-VITRO - EFFECTS OF GM1 GANGLIOSIDE AND PROTEIN-SYNTHESIS INHIBITION

被引：11

作者：

HEATON, MB

PAIVA, M

SWANSON, DJ

WALKER, DW

机构：

[1] UNIV FLORIDA,COLL MED,ALCOHOL RES CTR,GAINESVILLE,FL 32610

[2] UNIV FLORIDA,COLL MED,CTR NEUROBIOL SCI,GAINESVILLE,FL 32610

[3] DVA MED CTR,GAINESVILLE,FL 32610

来源：

BRAIN RESEARCH | 1994年 / 654卷 / 02期

关键词：

ETHANOL; ETHANOL NEUROTOXICITY; GM1; CYCLOHEXIMIDE; NEUROPROTECTION; SEPTOHIPPOCAMPAL SYSTEM; DORSAL ROOT GANGLIA;

D O I：

10.1016/0006-8993(94)90497-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cultures of septal and hippocampal neurons from fetal rat and dorsal root ganglion neurons from embryonic chick were pretreated with GM1 ganglioside or cycloheximide and then supplemented with toxic concentrations of ethanol. GM1 provided significant protection against ethanol neurotoxicity in each population. The inhibition of protein synthesis by cycloheximide, however, which protects against cell death resulting from withdrawal of neurotrophic factor support, did not ameliorate ethanol-induced neuronal loss.

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页码：336 / 342

页数：7

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