DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF GLICLAZIDE AND METFORMIN HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM BY SIMULTANEOUS EQUATION METHOD

被引：11
|
作者：
Dadhania, Ketan P. [1 ]
Nadpara, Parthika A. [2 ]
Agrawal, Yadvendra K. [3 ]
机构：
[1] Smt RD Gardi B Pharm Coll, Rajkot Jamnagar Highway, Rajkot, Gujarat, India
[2] Saurashtra Univ, Dept Pharmaceut Sci, Rajkot, Gujarat, India
[3] Forens Sci Univ, Inst Res & Dev, Ganhinagar, Gujarat, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2011年 / 2卷 / 06期
关键词：
Gliclazide; Metformin hydrochloride; Spectrophotometric method; Simultaneous Equation;
D O I：
10.13040/IJPSR.0975-8232.2(6).1559-63
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A simple, rapid, accurate, precise, specific and economical spectrophotometric method for simultaneous estimation of Gliclazide (GLC) and Metformin hydrochloride (MET) in combined tablet dosage form has been developed. It employs formation and solving of simultaneous equation using two wavelengths 227.0 nm and 237.5 nm. This method obeys Beer's law in the employed concentration ranges of 5-25 mu g/ml and 2.5-12.5 mu g/ml for Gliclazide and Metformin hydrochloride, respectively. Results of analysis were validated statistically and by recovery studies.
引用
收藏
页码：1559 / 1563
页数：5
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