Effects of Nattokinase on Whole Blood Viscosity and Mortality

被引:0
作者
Cengiz, Melike [1 ]
Karadamar, Pinar [2 ]
Yilmaz, Murat [1 ]
Coskunfirat, Nesil [1 ]
Ramazanoglu, Atilla [1 ]
Ozdem, Sabahat [3 ]
Baskurt, Oguz Kerim [2 ]
Meiselman, Herbert J. [4 ]
机构
[1] Akdeniz Univ, Tip Fak, Anesteziyol & Reanimasyon Anabilim Dali, Antalya, Turkey
[2] Akdeniz Univ, Tip Fak, Fizyol Anabilim Dali, Antalya, Turkey
[3] Akdeniz Univ, Tip Fak, Biyokimya Anabilim Dali, Antalya, Turkey
[4] Keck Sch Med, Fizyol & Biyofizik Dept, Los Angeles, CA USA
来源
JOURNAL OF THE TURKISH SOCIETY OF INTENSIVE CARE-TURK YOGUN BAKM DERNEGI DERGISI | 2011年 / 9卷 / 03期
关键词
Nattokinase; sepsis; fibrinogen; viscosity;
D O I
10.4274/tybdd.09.16
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Objective: Nattokinase is a serin protease having potent fibrinolytic effect derived from fermentation of boiled soy bean by the use of Basillus Subtilis Natto. The aim of this experimental study is to investigate the effects of intragastric Nattokinase (6 mg/day) administration for 7 days prior to formation of sepsis on plasma fibrinogen levels, whole blood viscosity and mortality in rats. Materials and Methods: Intraabdominal sepsis were performed by cecal ligation and puncture in rats supplemented with nattokinase or olive oil for 7 days prior to sepsis formation. Plasma fibrinogen, whole blood viscosity analysis and survival analysis was performed after intraabdominal sepsis formation. Results: Mean blood viscosity of rats was lower in Nattokinase and cecal ligation group at lowest shear rate (p<0.05). However, the differences between groups were not significant at higher shear rates. No difference was found in survival rates and survival times of Nattokinase and cecal ligation and cecal ligation and puncture groups. Conclusion: Our results were unable to show the effects of intragastric nattokinase supplementation prior to sepsis on plasma fibrinogen levels or whole blood viscosity, except low shear rate. Nattokinase did not altered survival in septic rats.
引用
收藏
页码:85 / 89
页数:5
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