PATHOGENESIS OF SIVMAC INFECTION IN CHINESE AND INDIAN RHESUS MACAQUES - EFFECTS OF SPLENECTOMY ON VIRUS BURDEN

被引：131

作者：

JOAG, SV ^{[1
]}

STEPHENS, EB ^{[1
]}

ADAMS, RJ ^{[1
]}

FORESMAN, L ^{[1
]}

NARAYAN, O ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DIV COMPARAT MED,BALTIMORE,MD 21205

来源：

VIROLOGY | 1994年 / 200卷 / 02期

关键词：

D O I：

10.1006/viro.1994.1207

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The spleen and lymph nodes are the predominant sites of viral replication in SIV and HIV infections. We studied splenectomized and control unsplenectomized rhesus macaques of both the Indian and the Chinese subspecies of Macaca mulatta. All animals were inoculated with SIV(mac)239, a molecularly cloned strain of SIV. Our data showed: (1) splenectomized animals, particularly among the Indian subspecies, had a lower virus burden and longer survival than unsplenectomized controls, (2) the Chinese macaques controlled virus replication more effectively than did the Indian animals, and (3) that a higher infectious virus burden was present in LN/spleen than in blood in both splenectomized and control animals. (C) 1994 Academic Press, Inc.

引用

页码：436 / 446

页数：11

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