REBOUND HYPERTENSION AFTER DISCONTINUATION OF TRANSDERMAL CLONIDINE THERAPY

被引：28

作者：

METZ, S ^{[1
]}

KLEIN, C ^{[1
]}

MORTON, N ^{[1
]}

机构：

[1] VET ADM MED CTR,DENVER,CO 80220

来源：

AMERICAN JOURNAL OF MEDICINE | 1987年 / 82卷 / 01期

关键词：

D O I：

10.1016/0002-9343(87)90371-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Three (and possibly all four) elderly hypertensive patients who were followed sequentially after discontinuation of transdermal clonidine monotherapy manifested a rapid rise in blood pressure to levels above control (pre- and post-therapy) readings. No signs of an overshoot" in plasma norepinephrine levels or symptoms of beta-adrenergic overactivity were seen. Such rebound hypertension suggests hypersensitivity to alpha-adrenergic receptor stimulation and could pose a heretofore unreported potential hazard to elderly or otherwise compromised patients who discontinue transdermal clonidine therapy. © 1987."

引用

页码：17 / 19

页数：3

共 11 条

[1] DEVELOPMENT OF A RIA FOR CLONIDINE AND ITS COMPARISON WITH THE REFERENCE METHODS [J].