THE VEGETALIZING FACTOR FROM CHICKEN EMBRYOS - ITS EDF (ACTIVIN-A)-LIKE ACTIVITY

被引：40

作者：

ASASHIMA, M

UCHIYAMA, H

NAKANO, H

ETO, Y

EJIMA, D

SUGINO, H

DAVIDS, M

PLESSOW, S

BORN, J

HOPPE, P

TIEDEMANN, H

机构：

[1] FREE UNIV BERLIN, INST MOLEK BIOL & BIOCHEM, ARNIMALLEE 22, W-1000 BERLIN 33, GERMANY

[2] YOKOHAMA CITY UNIV, DEPT BIOL, YOKOHAMA, KANAGAWA 232, JAPAN

[3] INST PHYS & CHEM RES RIKEN, FRONTIER RES PROGRAM, WAKO, SAITAMA 35101, JAPAN

[4] AJINOMOTO CO INC, CENT RES LABS, KAWASAKI, KANAGAWA 210, JAPAN

来源：

MECHANISMS OF DEVELOPMENT | 1991年 / 34卷 / 2-3期

关键词：

VEGETALIZING FACTOR; MESODERM AND ENDODERM INDUCTION IN AMPHIBIA; EDF (ERYTHROID DIFFERENTIATION FACTOR)-ACTIVITY; ACTIVIN;

D O I：

10.1016/0925-4773(91)90050-G

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The erythroid differentiation capacity of the HPLC-purified mesoderm- and endoderm-inducing vegetalizing factor from chicken embryos and of recombinant erythroid differentiation factor (EDF = activin A), an evolutionary highly conserved member of the TGF-beta protein superfamily have been compared. Both factors stimulate the synthesis of hemoglobin in erythroleukemia cells in the same concentration range. The EDF-activity of the mesoderm-inducing HPLC-fractions is inhibited by follistatin, an EDF-binding protein. The factor induces in ectoderm of Triturus taeniatus all kinds of mesodermal organs. The wide spectrum of organs is very likely to be induced by secondary interactions. At higher concentration (15 ng/ml), notochord- and endoderm-like tissues are induced in a high percentage.

引用

页码：135 / 141

页数：7

共 47 条

[1]

ALBANO RM, 1990, DEVELOPMENT, V110, P435

[2] FORMATION OF MESODERMAL PATTERN BY SECONDARY INDUCING INTERACTIONS [J].

ASAHI, K ;

BORN, J ;

TIEDEMANN, H ;

TIEDEMANN, H .

WILHELM ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY, 1979, 187 (03) :231-244

[3]

ASAHIMA M, 1990, ROUX ARCH DEV BIOL, V198, P330

[4] THE VEGETALIZING FACTOR BELONGS TO A FAMILY OF MESODERM-INDUCING PROTEINS RELATED TO ERYTHROID-DIFFERENTIATION FACTOR [J].

ASASHIMA, M ;

NAKANO, H ;

UCHIYAMA, H ;

DAVIDS, M ;

PLESSOW, S ;

LOPPNOWBLINDE, B ;

HOPPE, P ;

DAU, H ;

TIEDEMANN, H .

NATURWISSENSCHAFTEN, 1990, 77 (08) :389-391

[5] VERSUCHE ZUR DETERMINATION VON EMBRYONALEM AMPHIBIENGEWEBE DURCH INDUKTIONSSTOFFE IN LOSUNG [J].

BECKER, U ;

TIEDEMANN, H .

ZEITSCHRIFT FUR NATURFORSCHUNG PART B-CHEMIE BIOCHEMIE BIOPHYSIK BIOLOGIE UND VERWANDTEN GEBIETE, 1959, 14 (8-9) :608-609

[6] ACTIVATION OF MASKED NEURAL DETERMINANTS IN AMPHIBIAN EGGS AND EMBRYOS AND THEIR RELEASE FROM THE INDUCING TISSUE [J].

BORN, J ;

JANECZEK, J ;

SCHWARZ, W ;

TIEDEMANN, H ;

TIEDEMANN, H .

CELL DIFFERENTIATION AND DEVELOPMENT, 1989, 27 (01) :1-7

[7] ISOLATION OF A VEGETALIZING INDUCING FACTOR [J].

BORN, J ;

TIEDEMANN, H ;

KOCHERBE.U ;

GEITHE, HP .

HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1972, 353 (07) :1075-+

[8] PROTEIN-KINASES IN AMPHIBIAN ECTODERM INDUCED FOR NEURAL DIFFERENTIATION [J].

DAVIDS, M .

ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY, 1988, 197 (06) :339-344

[9] A VEGETALIZING INDUCING FACTOR - ISOLATION AND CHEMICAL-PROPERTIES [J].

GEITHE, HP ;

ASASHIMA, M ;

ASAHI, K ;

BORN, J ;

TIEDEMANN, H ;

TIEDEMANN, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1981, 676 (03) :350-356

[10] A MESODERM-INDUCING FACTOR FROM A XENOPUS-LAEVIS CELL-LINE - CHEMICAL-PROPERTIES AND RELATION TO THE VEGETALIZING FACTOR FROM CHICKEN EMBRYOS [J].

GRUNZ, H ;

BORN, J ;

DAVIDS, M ;

HOPPE, P ;

LOPPNOWBLINDE, B ;

TACKE, L ;

TIEDEMANN, H ;

TIEDEMANN, H .

ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY, 1989, 198 (01) :8-13

← 1 2 3 4 5 →