DIFFERENCES BETWEEN MUSCARINIC-RECEPTOR-INDUCED AND CA-2+-INDUCED INOSITOL POLYPHOSPHATE ISOMER ACCUMULATION IN RAT CEREBRAL-CORTEX SLICES

被引：21
作者：
BAIRD, JG
NAHORSKI, SR
机构：
[1] Department of Pharmacology, University of Leicester, Medical Sciences Building, Leicester LE1 9HN, University Road
来源：
BIOCHEMICAL JOURNAL | 1990年 / 267卷 / 03期
关键词：
D O I：
10.1042/bj2670835
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Muscarinic-receptor stimulation or depolarization by elevated K+ leads to increased accumulation of [3H]Ins(1,4,5)P3, [3H]Ins(1,3,4,5)P4 and several degradation products of these polyphosphates separated by h.p.l.c. On the other hand, agents such as ionomycin and maitotoxin, which increase intracellular Ca2+ directly, produce a small accumulation of [3H]Ins(1,4,5)P3 and markedly increase [3H]Ins(1,4)P2, but [3H]Ins(1,3,4,5)P3, [3H]Ins(1,3,4)P3 and [3H]Ins(1,3)P2 are virtually unaffected. Ca2+-dependent [3H]inositol polyphosphate metabolism may involve different pools of lipids and/or phosphoinositidases.
引用
收藏
页码：835 / 838
页数：4
相关论文
共 36 条
[1]   MEMBRANE DEPOLARIZATION AND CARBAMOYLCHOLINE STIMULATE PHOSPHATIDYLINOSITOL TURNOVER IN INTACT NERVE-TERMINALS [J].
AUDIGIER, SMP ;
WANG, JKT ;
GREENGARD, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (08) :2859-2863
[2]   DIFFERENCES IN [H-3]INOSITOL PHOSPHATE PRODUCTION BETWEEN THE NEURONAL CELL-LINE (SH-SY5Y) AND CEREBRAL-CORTEX SLICES IN RESPONSE TO AGENTS WHICH RAISE INTRACELLULAR CALCIUM [J].
BAIRD, JG ;
LAMBERT, DG ;
NAHORSKI, SR .
BIOCHEMICAL SOCIETY TRANSACTIONS, 1989, 17 (03) :570-571
[3]   DUAL EFFECTS OF K+ DEPOLARIZATION ON INOSITOL POLYPHOSPHATE PRODUCTION IN RAT CEREBRAL-CORTEX [J].
BAIRD, JG ;
NAHORSKI, SR .
JOURNAL OF NEUROCHEMISTRY, 1989, 53 (03) :681-685
[4]   POTASSIUM DEPOLARIZATION MARKEDLY ENHANCES MUSCARINIC RECEPTOR STIMULATED INOSITOL TETRAKISPHOSPHATE ACCUMULATION IN RAT CEREBRAL CORTICAL SLICES [J].
BAIRD, JG ;
NAHORSKI, SR .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 141 (03) :1130-1137
[5]   INCREASED INTRACELLULAR CALCIUM STIMULATES H-3 INOSITOL POLYPHOSPHATE ACCUMULATION IN RAT CEREBRAL CORTICAL SLICES [J].
BAIRD, JG ;
NAHORSKI, SR .
JOURNAL OF NEUROCHEMISTRY, 1990, 54 (02) :555-561
[6]  
BANSAL VS, 1987, J BIOL CHEM, V262, P9444
[7]   DIFFERENTIAL-EFFECTS OF LITHIUM ON MUSCARINIC RECEPTOR STIMULATION OF INOSITOL PHOSPHATES IN RAT CEREBRAL-CORTEX SLICES [J].
BATTY, I ;
NAHORSKI, SR .
JOURNAL OF NEUROCHEMISTRY, 1985, 45 (05) :1514-1521
[8]   LITHIUM INHIBITS MUSCARINIC-RECEPTOR-STIMULATED INOSITOL TETRAKISPHOSPHATE ACCUMULATION IN RAT CEREBRAL-CORTEX [J].
BATTY, I ;
NAHORSKI, SR .
BIOCHEMICAL JOURNAL, 1987, 247 (03) :797-800
[9]   ACCUMULATION OF INOSITOL POLYPHOSPHATE ISOMERS IN AGONIST-STIMULATED CEREBRAL-CORTEX SLICES - COMPARISON WITH METABOLIC PROFILES IN CELL-FREE PREPARATIONS [J].
BATTY, IH ;
LETCHER, AJ ;
NAHORSKI, SR .
BIOCHEMICAL JOURNAL, 1989, 258 (01) :23-32
[10]   INOSITOL PHOSPHATES AND CELL SIGNALING [J].
BERRIDGE, MJ ;
IRVINE, RF .
NATURE, 1989, 341 (6239) :197-205
1234