LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 OVEREXPRESSION AND T-CELL AUTOREACTIVITY

被引：83

作者：

RICHARDSON, B

POWERS, D

HOOPER, F

YUNG, RL

OROURKE, K

机构：

[1] UNIV MICHIGAN,ANN ARBOR,MI 48109

[2] ANN ARBOR VET ADM HOSP,ANN ARBOR,MI

[3] BOWMAN GRAY SCH MED,WINSTON SALEM,NC

来源：

ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 09期

关键词：

D O I：

10.1002/art.1780370915

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To determine if DNA methylation inhibitors make T cells autoreactive by inducing lymphocyte function-associated antigen type 1 (LFA-1) (CD11a/ CD18) overexpression. Methods. T cell clones were treated with 3 distinct DNA methylation inhibitors or were stably transfected with a CD18 cDNA in a mammalian expression vector, and the effects on LFA-1 expression and activation requirements were examined. Results. LFA-1 overexpression, caused by DNA methylation inhibitors or by transfection, correlates with the development of autoreactivity. Conclusion. LFA-1 overexpression may contribute to T cell autoreactivity.

引用

页码：1363 / 1372

页数：10

共 31 条

[1] COTRANSFECTION OF ICAM-1 AND HLA-DR RECONSTITUTES HUMAN ANTIGEN-PRESENTING CELL-FUNCTION IN MOUSE L-CELLS [J].