ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND OXYGEN-DERIVED FREE-RADICALS IN THE FORMATION OF GASTRIC-LESIONS INDUCED BY HCL/ETHANOL, AND A POSSIBLE MECHANISM OF PROTECTION BY ANTIULCER POLYSACCHARIDE

被引:44
作者
MATSUMOTO, T
MORIGUCHI, R
YAMADA, H
机构
[1] KITASATO INST, ORIENTAL MED RES CTR, 5-9-1 SHIROKANE, MINATO KU, TOKYO 108, JAPAN
[2] KITASATO INST, RES DEPT, MINATO KU, TOKYO 108, JAPAN
关键词
D O I
10.1111/j.2042-7158.1993.tb05594.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study examined the role of oxygen-derived free radicals in the pathogenesis of gastric mucosal lesions induced by HCI/ethanol. Superoxide dismutase, and catalase, and their combination reduced gastric lesion formation in mice. Gastric lesions were also reduced in mice treated with cyclophosphamide or anti-neutrophils, but not in mice treated with allopurinol or desulphated-carrageenan. Cobra venom factor did not reduce lesion formation. These results suggested that oxygen-free radicals may contribute to the formation of gastric mucosal lesions induced by HCI/ethanol, and that oxygen radicals were generated from neutrophils but not from xanthine oxidase. Anti-ulcer pectic polysaccharide, bupleuran 2IIc, which was recently isolated from the roots of Bupleurum falcatum L., showed potent inhibition of HCI/ethanol-induced gastric lesions in mice. Bupleuran 2IIc seemed to scavenge hydroxyl radical effectively. It was suggested that this anti-ulcer polysaccharide may provide protection to the gastric mucosa by scavenging oxygen-free radicals.
引用
收藏
页码:535 / 539
页数:5
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