ADENYLATE-CYCLASE FROM HIRUDO-MEDICINALIS SEGMENTAL GANGLIA - MODULATION BY PHYSIOLOGICAL AND NONPHYSIOLOGICAL AGENTS

被引：5
作者：
FERRETTI, ME [1 ]
PARESCHI, MC [1 ]
CAMPI, AL [1 ]
CAVALLARO, R [1 ]
BUZZI, M [1 ]
BIONDI, C [1 ]
机构：
[1] UNIV FERRARA,DEPT CHEM,I-44100 FERRARA,ITALY
来源：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1992年 / 103卷 / 03期
关键词：
D O I：
10.1016/0742-8413(92)90173-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In Hirudo medicinalis segmental ganglia GTP is essential for the full expression of the stimulatory action of serotonin on the adenylate cyclase activity. The amine, in turn, increases the overall affinity of the enzymatic system for GTP. 2. GTPgammaS and Gpp(NH)p, non-hydrolysable analogues of GTP, dose-dependently enhance the basal enzyme activity, but impair the stimulatory effect of serotonin. 3. Fluoride ions biphasically modulate the leech adenylate cyclase both in the absence and in the presence of GTP. The ion effect is also influenced by non-physiological guanine nucleotides
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页码：503 / 510
页数：8
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