TPA-INDUCED ACTIVATION OF MAP KINASE

被引：69

作者：

ADAMS, PD ^{[1
]}

PARKER, PJ ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND,PROT PHOSPHORYLAT LAB,44 LINCOLNS INN FIELDS,LONDON WC2A 3PX,ENGLAND

来源：

FEBS LETTERS | 1991年 / 290卷 / 1-2期

关键词：

MAP KINASE; PROTEIN KINASE-C; PHORBOL ESTER;

D O I：

10.1016/0014-5793(91)81230-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Threonine and tyrosine residue phosphorylation of a 42 kDa protein identified as mitogen-activated protein kinase (MAP kinase) was stimulated in extracts from TPA-pretreated cells. It is further shown that TPA pretreatment leads to the enhancement of an activity that will induce reactivation of dephosphorylated/inactivated MAP kinase. This TPA-induced activity induces the threonine and tyrosine phosphorylation of p42 in extracts from unstimulated cells.

引用

页码：77 / 82

页数：6

共 28 条

[1] AHN NG, 1991, J BIOL CHEM, V266, P4220
[2] AHN NG, 1990, J BIOL CHEM, V265, P11487
[3] ALLEMAIN GL, 1991, MOL CELL BIOL, V11, P1002
[4] REQUIREMENT FOR INTEGRATION OF SIGNALS FROM 2 DISTINCT PHOSPHORYLATION PATHWAYS FOR ACTIVATION OF MAP KINASE
ANDERSON, NG
MALLER, JL
TONKS, NK
STURGILL, TW
[J]. NATURE, 1990, 343 (6259) : 651 - 653
[5] THE PHORBOL ESTER RECEPTOR - A PHOSPHOLIPID-REGULATED PROTEIN-KINASE
ASHENDEL, CL
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 822 (02) : 219 - 242
[6] SEPARATION AND CHARACTERIZATION OF MICROTUBULE PROTEINS FROM CALF BRAIN
BERKOWITZ, SA
KATAGIRI, J
BINDER, HK
WILLIAMS, RC
[J]. BIOCHEMISTRY, 1977, 16 (25) : 5610 - 5617
[7] PURIFICATION AND PROPERTIES OF EXTRACELLULAR SIGNAL-REGULATED KINASE-1, AN INSULIN-STIMULATED MICROTUBULE-ASSOCIATED PROTEIN-2 KINASE
BOULTON, TG
GREGORY, JS
COBB, MH
[J]. BIOCHEMISTRY, 1991, 30 (01) : 278 - 286
[8] AN INSULIN-STIMULATED PROTEIN-KINASE SIMILAR TO YEAST KINASES INVOLVED IN CELL-CYCLE CONTROL
BOULTON, TG
YANCOPOULOS, GD
GREGORY, JS
SLAUGHTER, C
MOOMAW, C
HSU, J
COBB, MH
[J]. SCIENCE, 1990, 249 (4964) : 64 - 67
[9] ERKS - A FAMILY OF PROTEIN-SERINE THREONINE KINASES THAT ARE ACTIVATED AND TYROSINE PHOSPHORYLATED IN RESPONSE TO INSULIN AND NGF
BOULTON, TG
NYE, SH
ROBBINS, DJ
IP, NY
RADZIEJEWSKA, E
MORGENBESSER, SD
DEPINHO, RA
PANAYOTATOS, N
COBB, MH
YANCOPOULOS, GD
[J]. CELL, 1991, 65 (04) : 663 - 675
[10] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

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