METAL-COMPLEXES OF THE ANTIINFLAMMATORY DRUG PIROXICAM

The synthesis and characterization of Fe(II), Co(II), Zn(II), and Cd(II) complexes with a potent antiinflammatory drug piroxicam [4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide] are described. The crystal and molecular structures of M(Pir)2(DMF)2 (M = Cu, Cd; Pir = piroxicam; DMF = N,N-dimethylformamide) are also reported. Crystallographic data are as follows: Cd(Pir)2(DMF)2, monoclinic, P2(1)/c, a = 9.890 (2) angstrom, b = 8.076 (2) angstrom, c = 24.998 (4) angstrom, beta = 100.16 (2)degrees, Z = 2. The structure was refined to R(F(o)) = 0.039 for 2321 reflections with I > 3-sigma(I). Cu(Pir)2(DMF)2, monoclinic, P2(1)/c, a = 10.142 (2) angstrom, b = 7.855 (3) angstrom, c = 24.053 (4) angstrom, beta = 97.79 (2)degrees, Z = 2. The refinement yielded the final R(F(o)) of 0.059 for 797 reflections with I > 3-sigma(I). Both Cd(II) and Cu(II) ions bind to the piroxicam molecule through its amide O and pyridyl N atoms.