A DOPAMINE-SENSITIVE AND OCTOPAMINE-SENSITIVE ADENYLATE-CYCLASE IN THE NERVOUS-SYSTEM OF OCTOPUS-VULGARIS

被引：8

作者：

CAPASSO, A ^{[1
]}

CARGINALE, V ^{[1
]}

MADONNA, L ^{[1
]}

MANCANIELLO, D ^{[1
]}

SCUDIERO, R ^{[1
]}

DEPRISCO, PP ^{[1
]}

DEPETROCELLIS, B ^{[1
]}

PARISI, E ^{[1
]}

机构：

[1] CNR,INST PROT BIOCHEM & ENZYMOL,VIA TOIANO 6,I-80072 ARCO FELICE,ITALY

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1991年 / 100卷 / 04期

关键词：

D O I：

10.1016/0305-0491(91)90294-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Adenylate cyclase activity was assayed in the optic lobe of Octopus vulgaris. 2. Both octopamine and dopamine stimulate the octopus adenylate cyclase, apparently by competing with the same receptor site. 3. (+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene-HBr (6,7-ADTN) and a number of phenylethanolamine derivatives stimulate the octopus adenylate cyclase activity. 4. The dopamine D-1 antagonists R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-HCl (SCH-23390) and (+/-)-7-bromo-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-HCl (SKF-83566) are unable to antagonize the effects of dopamine and octopamine, and similarly ineffective is the agonist (+/-)-l-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol-HCl (SKF-38393). 5. No detectable binding of labelled SCH-23390 occurs on membrane preparations from octopus optic lobe.

引用

页码：805 / 808

页数：4

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