NEGATIVE REGULATION OF THE GROWTH-PROMOTING TRANSCRIPTION FACTOR E2F-1 BY A STABLY BOUND CYCLIN A-DEPENDENT PROTEIN-KINASE

被引:441
作者
KREK, W [1 ]
EWEN, ME [1 ]
SHIRODKAR, S [1 ]
ARANY, Z [1 ]
KAELIN, WG [1 ]
LIVINGSTON, DM [1 ]
机构
[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0092-8674(94)90582-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cyclin A-kinase, an enzyme required for coordinating S phase progression, forms stable in vivo complexes with E2F-1, a growth-promoting transcription factor, which binds to the retinoblastoma gene product and is involved in the timely activation of genes whose products contribute to G1 exit and S phase traversal. Complex formation results in a negative biochemical effect of cyclin A-kinase: the shut-off of E2F-1-dependent DNA binding function in S/G2. Thus, specific and timely cell cycle-dependent interactions of E2F-1 with proteins that inhibit its function (i.e., RB during G1 and cyclin A-kinase during S/G2) may contribute to the periodicity of expression of certain E2F-1-responsive genes at the G1/S transition.
引用
收藏
页码:161 / 172
页数:12
相关论文
共 44 条
[1]   MECHANISMS THAT HELP THE YEAST-CELL CYCLE CLOCK TICK - G2 CYCLINS TRANSCRIPTIONALLY ACTIVATE G2 CYCLINS AND REPRESS G1 CYCLINS [J].
AMON, A ;
TYERS, M ;
FUTCHER, B ;
NASMYTH, K .
CELL, 1993, 74 (06) :993-1007
[2]   FUNCTIONAL SYNERGY BETWEEN DP-1 AND E2F-1 IN THE CELL CYCLE-REGULATING TRANSCRIPTION FACTOR DRTF1/E2F [J].
BANDARA, LR ;
BUCK, VM ;
ZAMANIAN, M ;
JOHNSTON, LH ;
LATHANGUE, NB .
EMBO JOURNAL, 1993, 12 (11) :4317-4324
[3]   INDEPENDENT BINDING OF THE RETINOBLASTOMA PROTEIN AND P107 TO THE TRANSCRIPTION FACTOR E2F [J].
CAO, L ;
FAHA, B ;
DEMBSKI, M ;
TSAI, LH ;
HARLOW, E ;
DYSON, N .
NATURE, 1992, 355 (6356) :176-179
[4]   CELL CYCLE-SPECIFIC ASSOCIATION OF E2F WITH THE P130 E1A-BINDING PROTEIN [J].
COBRINIK, D ;
WHYTE, P ;
PEEPER, DS ;
JACKS, T ;
WEINBERG, RA .
GENES & DEVELOPMENT, 1993, 7 (12A) :2392-2404
[5]   ACTIVATION OF HUMAN CYCLIN-DEPENDENT KINASES INVITRO [J].
DESAI, D ;
GU, Y ;
MORGAN, DO .
MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (05) :571-582
[6]   A CYCLIN-A-PROTEIN KINASE COMPLEX POSSESSES SEQUENCE-SPECIFIC DNA-BINDING ACTIVITY - P33CDK2 IS A COMPONENT OF THE E2F-CYCLIN-A COMPLEX [J].
DEVOTO, SH ;
MUDRYJ, M ;
PINES, J ;
HUNTER, T ;
NEVINS, JR .
CELL, 1992, 68 (01) :167-176
[7]   CDK2 ENCODES A 33-KDA CYCLIN-A-ASSOCIATED PROTEIN-KINASE AND IS EXPRESSED BEFORE CDC2 IN THE CELL-CYCLE [J].
ELLEDGE, SJ ;
RICHMAN, R ;
HALL, FL ;
WILLIAMS, RT ;
LODGSON, N ;
HARPER, JW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2907-2911
[8]   INTERACTION OF P107 WITH CYCLIN-A INDEPENDENT OF COMPLEX-FORMATION WITH VIRAL ONCOPROTEINS [J].
EWEN, ME ;
FAHA, B ;
HARLOW, E ;
LIVINGSTON, DM .
SCIENCE, 1992, 255 (5040) :85-87
[9]   INTERACTION BETWEEN HUMAN CYCLIN-A AND ADENOVIRUS E1A-ASSOCIATED P107 PROTEIN [J].
FAHA, B ;
EWEN, ME ;
TSAI, LH ;
LIVINGSTON, DM ;
HARLOW, E .
SCIENCE, 1992, 255 (5040) :87-90
[10]  
FARNHAM PJ, 1985, J BIOL CHEM, V260, P7675