IMMUNOPATHOLOGICAL STUDY OF EOSINOPHILS IN EOSINOPHILIC GRANULOMA OF BONE - EVIDENCE FOR RELEASE OF 3 CATIONIC PROTEINS AND SUBSEQUENT UPTAKE IN MACROPHAGES

被引：11

作者：

JANIN, A ^{[1
]}

TORPIER, G ^{[1
]}

CAPRON, M ^{[1
]}

COURTIN, P ^{[1
]}

GOSSELIN, B ^{[1
]}

机构：

[1] INST PASTEUR,CNRS 624,INSERM,UNITE MIXTE U167,CTR IMMUNOL & BIOL PARASITAIRE,F-59000 LILLE,FRANCE

来源：

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1992年 / 421卷 / 03期

关键词：

EOSINOPHILIC GRANULOMA OF BONE; EOSINOPHIL GRANULE PROTEINS; IMMUNOSTAINING; ULTRASTRUCTURE;

D O I：

10.1007/BF01611183

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Eosinophils from two patients with eosinophilic granuloma of bone (EGB) were studied by combined immunohistochemical and immuno-ultrastructural methods with antibodies directed against three eosinophil granule proteins: major basic protein, eosinophil cationic protein, and eosinophil peroxidase. Immunohistostaining showed the presence and distribution of large numbers of eosinophils in the granuloma. Immuno-ultrastructural methods showed alterations of eosinophil fine structure associated with some steps in the release of granule proteins. No granule extrusion was seen, but rather cationic proteins diffused within cytoplasmic tubulo-vesicular structures. Furthermore, the three granule proteins were found within phagolysosomes of surrounding macrophages, suggesting an interaction between eosinophils and phagocytic cells at the destructive stage of EGB.

引用

页码：255 / 261

页数：7

共 37 条

[11] BULLOUS PEMPHIGOID, AN ULTRASTRUCTURAL-STUDY OF THE INFLAMMATORY RESPONSE - EOSINOPHIL, BASOPHIL AND MAST-CELL GRANULE CHANGES IN MULTIPLE BIOPSIES FROM ONE PATIENT [J].