HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF CHLORHEXIDINE PHOSPHANILATE, A NEW ANTIMICROBIAL AGENT

被引：4
作者：
GADDE, RR
MCNIFF, EF
PEER, MM
机构：
[1] Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Buffalo, NY 14213
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1991年 / 9卷 / 10-12期
关键词：
CHLORHEXIDINE PHOSPHANILATE; CHLORHEXIDINE; PHOSPHANILIC ACID; HPLC; STOICHIOMETRY; STABILITY; CHLORHEXIDINE ACETATE;
D O I：
10.1016/0731-7085(91)80040-G
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Chlorhexidine phosphanilate (CHP) is analysed by two separate reversed-phase HPLC methods. CHP was found to be a non-stoichiometric compound with a phosphanilic acid to chlorhexidine ratio of 1.83. By careful choice of solvents, solution pH and HPLC columns, loss of sample due to incomplete dissolution and adsorption to surfaces is avoided. Both methods are shown to be stability-indicating and accurate.
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页码：1031 / 1036
页数：6
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