CIPROFLOXACIN-INDUCED GRANULOMATOUS INTERSTITIAL NEPHRITIS AND LOCALIZED ELASTOLYSIS

被引：35

作者：

LIEN, YHH ^{[1
]}

HANSEN, R ^{[1
]}

KERN, WF ^{[1
]}

BANGERT, J ^{[1
]}

NAGLE, RB ^{[1
]}

KO, M ^{[1
]}

SISKIND, MS ^{[1
]}

机构：

[1] UNIV ARIZONA,HLTH SCI CTR,DEPT PATHOL,TUCSON,AZ 85724

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1993年 / 22卷 / 04期

关键词：

GRANULOMATOUS INTERSTITIAL NEPHRITIS; ACUTE RENAL FAILURE; STEROID THERAPY; CELL-MEDIATED IMMUNITY; ELASTOLYSIS;

D O I：

10.1016/S0272-6386(12)80936-X

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Ciprofloxacin is known to cause acute interstitial nephritis. We report the first case of ciprofloxacin-induced granulomatous interstitial nephritis and localized elastolysis. The patient presented with acute renal failure and skin lesions following a 14-day course of ciprofloxacin administered for cellulitis. The patient had symmetric, palm-sized, tender violaceous plaques on both axillae. The renal biopsy revealed granulomatous interstitial disease. A skin biopsy revealed an elastolytic process with histocytic infiltration and calcification. After discontinuing ciprofloxacin and starting a short course of steroid therapy, the skin lesion and renal function improved promptly. The nephritis relapsed after prednisone was discontinued and responded to a second course of steroid therapy. Ciprofloxacin, like penicillin, can cause granulomatous interstitial nephritis and elastolysis. A prolonged course of steroid therapy may be indicated in patients with ciprofloxacin-induced granulomatous interstitial nephritis to avoid early relapse. © 1993, National Kidney Foundation. All rights reserved. All rights reserved.

引用

页码：598 / 602

页数：5

共 14 条

[1] ACUTE-RENAL-FAILURE DUE TO CIPROFLOXACIN [J].