IMMUNOHISTOCHEMICAL LOCALIZATION OF AMYLOID BETA-PROTEIN DEPOSITS IN EXTRACEREBRAL TISSUES OF PATIENTS WITH ALZHEIMERS-DISEASE

被引：0

作者：

SKODRAS, G

PENG, JHF

PARKER, JC

KRAGEL, PJ

机构：

来源：

ANNALS OF CLINICAL AND LABORATORY SCIENCE | 1993年 / 23卷 / 04期

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D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

An autopsy study was conducted on patients with Alzheimer's disease in order to explore the possibility of amyloid beta-protein deposits in tissues other than the brain. Immunoperoxidase staining techniques were employed using an amyloid beta-protein antiserum as primary antibody; paraffin sections of kidney, liver, heart, lung, spleen, bone marrow, colon, stomach, adrenal, thyroid, and brain were examined. Our autopsy cases were divided into two groups. The first group comprised 10 patients with Alzheimer's disease. The second group consisted of eight control cases, of age-matched individuals, that died of unrelated causes and showed no clinicopathologic evidence of Alzheimer's disease. Identification was made of strong, although focal, positive staining in two kidneys and one lung of three different patients with Alzheimer's disease. All other tissues, including the control cases, showed negative staining.

引用

页码：275 / 280

页数：6

共 20 条

[1] EXPRESSION PATTERNS OF BETA-AMYLOID PRECURSOR PROTEIN (BETA-APP) IN NEURAL AND NONNEURAL HUMAN TISSUES FROM ALZHEIMERS-DISEASE AND CONTROL SUBJECTS [J].