RECENT STUDIES OF RIBONUCLEASE-P

被引：152

作者：

ALTMAN, S ^{[1
]}

KIRSEBOM, L ^{[1
]}

TALBOT, S ^{[1
]}

机构：

[1] UNIV UPPSALA, DEPT MICROBIOL, S-75105 UPPSALA, SWEDEN

来源：

FASEB JOURNAL | 1993年 / 7卷 / 01期

关键词：

TRANSFER RNA BIOSYNTHESIS; CATALYTIC RNA; RNA-PROTEIN INTERACTIONS; PHYLOGENETIC COMPARISONS;

D O I：

10.1096/fasebj.7.1.7916700

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNase P is an essential enzyme that is required for the biosynthesis of tRNA. It is composed of RNA and protein subunits. The RNA subunit of the enzyme derived from eubacterial sources can carry out the catalytic function by itself in vitro. Current studies of RNase P focus on structure-function relationships with respect to interactions of the RNA subunit with its substrates and with respect to the determination of the kinetic parameters of the reaction, the role of the protein component, and the rules governing recognition of substrates.

引用

页码：7 / 14

页数：8

共 60 条

[1]

ALTMAN S, 1989, ADV ENZYMOL RAMB, V62, P1

[2]

ALTMAN S, 1979, NONSENSE MUTATIONS T, P173

[3]

BAER MF, 1988, J BIOL CHEM, V263, P2344

[4] IDENTIFICATION AND CHARACTERIZATION OF AN RNA MOLECULE THAT COPURIFIES WITH RNASE P-ACTIVITY FROM HELA-CELLS [J].