A NEW GENERATION OF PHOSPHODIESTERASE INHIBITORS - MULTIPLE MOLECULAR-FORMS OF PHOSPHODIESTERASE AND THE POTENTIAL FOR DRUG SELECTIVITY

被引:309
作者
WEISHAAR, RE [1 ]
CAIN, MH [1 ]
BRISTOL, JA [1 ]
机构
[1] WARNER LAMBERT PARKE DAVIS PHARMACEUT RES, DEPT CHEM, ANN ARBOR, MI 48105 USA
关键词
D O I
10.1021/jm50001a001
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:537 / 545
页数:9
相关论文
共 96 条
[1]   ROLE OF CALCIUM AND CYCLIC ADENOSINE 3'-5' MONOPHOSPHATE IN REGULATING SMOOTH-MUSCLE CONTRACTION - MECHANISMS OF EXCITATION-CONTRACTION COUPLING IN SMOOTH-MUSCLE [J].
ADELSTEIN, RS ;
HATHAWAY, DR .
AMERICAN JOURNAL OF CARDIOLOGY, 1979, 44 (05) :783-787
[2]   CARDIOTONIC ACTIVITY OF AMRINONE-WIN 40680 [5-AMINO-3,4'-BIPYRIDIN-6(1H)-ONE] [J].
ALOUSI, AA ;
FARAH, AE ;
LESHER, GY ;
OPALKA, CJ .
CIRCULATION RESEARCH, 1979, 45 (05) :666-677
[3]  
Amer M S, 1975, Annu Rep Med Chem, V10, P192
[4]   STUDIES WITH PHOSPHODIESTERASE .3. 2 FORMS OF ENZYME FROM HUMAN BLOOD-PLATELETS [J].
AMER, MS ;
MAYOL, RF .
BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 309 (01) :149-156
[5]  
Appleman M M, 1975, Adv Cyclic Nucleotide Res, V5, P153
[6]  
ASANO T, 1977, MOL PHARMACOL, V13, P400
[7]  
BEAVO JA, 1971, J BIOL CHEM, V246, P3841
[8]  
BERGSTRAND H, 1978, J BIOL CHEM, V253, P1881
[9]  
BERGSTRAND H, 1977, MOL PHARMACOL, V13, P38
[10]   PARTIAL-PURIFICATION AND CHARACTERIZATION OF ADENOSINE-3' AND GUANOSINE-3',5'-MONOPHOSPHATE PHOSPHODIESTERASES FROM HUMAN LUNG-TISSUE [J].
BERGSTRAND, H ;
LUNDQUIST, B .
BIOCHEMISTRY, 1976, 15 (08) :1727-1735