SIMPLE COMPOUNDS, 2-ALKYL-2-AMINO-1,3-PROPANEDIOLS HAVE POTENT IMMUNOSUPPRESSIVE ACTIVITY

被引：96

作者：

FUJITA, T

YONETA, M

HIROSE, R

SASAKI, S

INOUE, K

KIUCHI, M

HIRASE, S

ADACHI, K

ARITA, M

CHIBA, K

机构：

[1] TAITO CO LTD,RES LAB,NAGATA KU,KOBE 653,JAPAN

[2] YOSHITOMI PHARMACEUT IND LTD,RES LABS,IRUMA,SAITAMA 358,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 08期

关键词：

D O I：

10.1016/0960-894X(95)00126-E

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

ISP-I (myriocin, thermozymocidin) was structurally simplified to give 2-amino-2-alkyl-1,3-propanediols that were also potent immunosuppressants. Among the series, 2-amino-2-pentadecyl-1,3-propanediol most actively prolonged rat skin allograft survival and was more effective than ciclosporin.

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页码：847 / 852

页数：6

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