T-CELL ABNORMALITIES IN MIXED CONNECTIVE-TISSUE DISEASE COMPLICATED WITH KLINEFELTERS-SYNDROME

被引：11

作者：

ISHIHARA, K

YOSHIMURA, M

NAKAO, H

KANAKURA, Y

KANAYAMA, Y

MATSUZAWA, Y

机构：

[1] Department of Internal Medicine, Osaka University Medical School, Suita 565

来源：

INTERNAL MEDICINE | 1994年 / 33卷 / 11期

关键词：

CD57+/CD8+ T-LYMPHOCYTES; IL-2; PRODUCTION; DEHYDROEPIANDROSTERONE SULFATE;

D O I：

10.2169/internalmedicine.33.714

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a 28-year-old Japanese with Klinefelter's syndrome who developed mixed connective tissue disease (MCTD) and Sjogren syndrome. Previously being well, he presented with Raynaud's phenomenon, dry eye, fever and polyarthralgia. Clinical examinations revealed anti-nRNP autoantibody, leukopenia and lung fibrosis. Then he was found to have Klinefelter's syndrome. Flow cytometric analysis showed a relative increase of peripheral CD8+T lymphocytes carrying either HLA-DR or CD57. Lymphocyte IL-2 production induced in vitro by concanavalin A was decreased. Such T cell abnormalities may be implicated in the development of autoimmune disease in Klinefelter's syndrome.

引用

页码：714 / 717

页数：4

共 27 条

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