FUNCTIONS OF BASIC FIBROBLAST GROWTH-FACTOR AND NEUROTROPHINS IN THE DIFFERENTIATION OF HIPPOCAMPAL-NEURONS

被引：272

作者：

VICARIOABEJON, C

JOHE, KK

HAZEL, TG

COLLAZO, D

MCKAY, RDG

机构：

[1] Laboratory of Molecular Biology National Institute of Neurological Disorders, Stroke National Institutes of Health Bethesda

来源：

NEURON | 1995年 / 15卷 / 01期

关键词：

D O I：

10.1016/0896-6273(95)90068-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Restrictions in neuronal fate occur during the transition from a multipotential to a postmitotic cell. This and later steps in neuronal differentiation are determined by extracellular signals. We report that basic fibroblast growth factor is mitogenic for stem cells and is a differentiation factor for calbindin-expressing hippocampal neurons. The neurotrophin NT-3 is a differentiation factor for the same neurons but does not affect proliferation. NT-3 and brain-derived neurotrophic factor promote the maturation of neurons derived from stem cells that have been grown in vitro. These results define functions for basic fibroblast growth factor and neurotrophins in the differentiation processes that direct a multipotential stem cell to a specific neuronal fate.

引用

页码：105 / 114

页数：10

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