CARDIOTOXIC EFFECTS OF HIGH-DOSES OF CYCLOPHOSPHAMIDE IN ALBINO-RATS

被引:2
作者
KUMAR, S [1 ]
GUPTA, RK [1 ]
BHAKE, AS [1 ]
SAMAL, N [1 ]
机构
[1] MAHATMA GANDHI INST MED SCI,DEPT PHARMACOL,WARDHA 442102,MAHARASHTRA,INDIA
来源
ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE | 1992年 / 319卷
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D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A histopathological study of cyclophosphamide-induced cardiotoxicity has been conducted in 43 Swiss albino rats. Multiple interstitial myocardial haemorrhage, multifocal myofibre necrosis, inflammatory reaction, vascular changes, pericarditis and valvulitis, mainly in the heart ventricles, have been observed. Previous results have suggested that cyclophosphamide directly damages the vascular endothelium, followed by the extravasation of blood containing high levels of the drug, and resulting into a toxic damage of the muscle cells. Our results are in favor of this hypothesis.
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页码:58 / 65
页数:8
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