THE RAT DELTA-1 AND DELTA-2 SUBUNITS EXTEND THE EXCITATORY AMINO-ACID RECEPTOR FAMILY

被引:272
作者
LOMELI, H [1 ]
SPRENGEL, R [1 ]
LAURIE, DJ [1 ]
KOHR, G [1 ]
HERB, A [1 ]
SEEBURG, PH [1 ]
WISDEN, W [1 ]
机构
[1] UNIV HEIDELBERG,CTR MOLEC BIOL,MOLEC NEUROSCI LAB,INF 282,W-6900 HEIDELBERG,GERMANY
关键词
GLUTAMATE RECEPTOR; RAT BRAIN; PURKINJE CELL;
D O I
10.1016/0014-5793(93)81186-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25% and 18.5% to the non-NMDA and NMDA receptor subunits, respectively. The rat delta-2 gene is expressed predominantly in Purkinje cells of the cerebellum whereas only low levels of delta-1 transcripts are found in the adult brain. However, delta-1 gene expression undergoes a pronounced developmental peak, with particularly high mRNA levels in the caudate putamen of late embryonic/early postnatal stages.
引用
收藏
页码:318 / 322
页数:5
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