THE RAT DELTA-1 AND DELTA-2 SUBUNITS EXTEND THE EXCITATORY AMINO-ACID RECEPTOR FAMILY

被引：272

作者：

LOMELI, H ^{[1
]}

SPRENGEL, R ^{[1
]}

LAURIE, DJ ^{[1
]}

KOHR, G ^{[1
]}

HERB, A ^{[1
]}

SEEBURG, PH ^{[1
]}

WISDEN, W ^{[1
]}

机构：

[1] UNIV HEIDELBERG,CTR MOLEC BIOL,MOLEC NEUROSCI LAB,INF 282,W-6900 HEIDELBERG,GERMANY

来源：

FEBS LETTERS | 1993年 / 315卷 / 03期

关键词：

GLUTAMATE RECEPTOR; RAT BRAIN; PURKINJE CELL;

D O I：

10.1016/0014-5793(93)81186-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25% and 18.5% to the non-NMDA and NMDA receptor subunits, respectively. The rat delta-2 gene is expressed predominantly in Purkinje cells of the cerebellum whereas only low levels of delta-1 transcripts are found in the adult brain. However, delta-1 gene expression undergoes a pronounced developmental peak, with particularly high mRNA levels in the caudate putamen of late embryonic/early postnatal stages.

引用

页码：318 / 322

页数：5

共 30 条

[1] CLONING OF A NOVEL GLUTAMATE RECEPTOR SUBUNIT, GLUR5 - EXPRESSION IN THE NERVOUS-SYSTEM DURING DEVELOPMENT
BETTLER, B
BOULTER, J
HERMANSBORGMEYER, I
OSHEAGREENFIELD, A
DENERIS, ES
MOLL, C
BORGMEYER, U
HOLLMANN, M
HEINEMANN, S
[J]. NEURON, 1990, 5 (05) : 583 - 595
[2] CLONING OF A PUTATIVE GLUTAMATE RECEPTOR - A LOW AFFINITY KAINATE-BINDING SUBUNIT
BETTLER, B
EGEBJERG, J
SHARMA, G
PECHT, G
HERMANSBORGMEYER, I
MOLL, C
STEVENS, CF
HEINEMANN, S
[J]. NEURON, 1992, 8 (02) : 257 - 265
[3] MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF GLUTAMATE RECEPTOR SUBUNIT GENES
BOULTER, J
HOLLMANN, M
OSHEAGREENFIELD, A
HARTLEY, M
DENERIS, E
MARON, C
HEINEMANN, S
[J]. SCIENCE, 1990, 249 (4972) : 1033 - 1037
[4] CUENOD M, 1990, TRENDS PHARMACOL SCI, V11, P477
[5] CLONING OF A CDNA FOR A GLUTAMATE RECEPTOR SUBUNIT ACTIVATED BY KAINATE BUT NOT AMPA
EGEBJERG, J
BETTLER, B
HERMANSBORGMEYER, I
HEINEMANN, S
[J]. NATURE, 1991, 351 (6329) : 745 - 748
[6] MOLECULAR NEUROBIOLOGY OF GLUTAMATE RECEPTORS
GASIC, GP
HOLLMANN, M
[J]. ANNUAL REVIEW OF PHYSIOLOGY, 1992, 54 : 507 - 536
[7] MOLECULAR-STRUCTURE OF THE CHICK CEREBELLAR KAINATE-BINDING SUBUNIT OF A PUTATIVE GLUTAMATE RECEPTOR
GREGOR, P
MANO, I
MAOZ, I
MCKEOWN, M
TEICHBERG, VI
[J]. NATURE, 1989, 342 (6250) : 689 - 692
[8] THE KA-2 SUBUNIT OF EXCITATORY AMINO-ACID RECEPTORS SHOWS WIDESPREAD EXPRESSION IN BRAIN AND FORMS ION CHANNELS WITH DISTANTLY RELATED SUBUNITS
HERB, A
BURNASHEV, N
WERNER, P
SAKMANN, B
WISDEN, W
SEEBURG, PH
[J]. NEURON, 1992, 8 (04) : 775 - 785
[9] CLONING BY FUNCTIONAL EXPRESSION OF A MEMBER OF THE GLUTAMATE RECEPTOR FAMILY
HOLLMANN, M
OSHEAGREENFIELD, A
ROGERS, SW
HEINEMANN, S
[J]. NATURE, 1989, 342 (6250) : 643 - 648
[10] KATSUWADA T, 1992, NATURE, V358, P36

← 1 2 3 →