THE RAT DELTA-1 AND DELTA-2 SUBUNITS EXTEND THE EXCITATORY AMINO-ACID RECEPTOR FAMILY

被引：274

作者：

LOMELI, H ^{[1
]}

SPRENGEL, R ^{[1
]}

LAURIE, DJ ^{[1
]}

KOHR, G ^{[1
]}

HERB, A ^{[1
]}

SEEBURG, PH ^{[1
]}

WISDEN, W ^{[1
]}

机构：

[1] UNIV HEIDELBERG,CTR MOLEC BIOL,MOLEC NEUROSCI LAB,INF 282,W-6900 HEIDELBERG,GERMANY

来源：

FEBS LETTERS | 1993年 / 315卷 / 03期

关键词：

GLUTAMATE RECEPTOR; RAT BRAIN; PURKINJE CELL;

D O I：

10.1016/0014-5793(93)81186-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25% and 18.5% to the non-NMDA and NMDA receptor subunits, respectively. The rat delta-2 gene is expressed predominantly in Purkinje cells of the cerebellum whereas only low levels of delta-1 transcripts are found in the adult brain. However, delta-1 gene expression undergoes a pronounced developmental peak, with particularly high mRNA levels in the caudate putamen of late embryonic/early postnatal stages.

引用

页码：318 / 322

页数：5

共 30 条

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