IDENTIFICATION OF IMMUNOGENIC REGIONS IN HUMAN THYROTROPIN RECEPTOR FOR IMMUNOGLOBULIN-G OF PATIENTS WITH GRAVES-DISEASE

被引：58
作者：
MURAKAMI, M
MORI, M
机构：
[1] First Department of Internal Medicine, Gunma University, School of Medicine, Maebashi
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 01期
关键词：
D O I：
10.1016/0006-291X(90)91423-P
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To identify immunogenic regions in human thyrotropin (TSH) receptor for immunoglobulin G (IgG) of patients with Graves' disease, seven different peptides (each consisting of 14-29 residues long) corresponding to segments of the extracellular domain of the receptor were synthesized. Graves' sera and IgG significantly bound to two out of seven peptides (the amino acid sequence of peptide #1, HQEEDFRVTCKDIQRIPSLPPSTQT; that of peptide #5, LRQRKSVNALNSPLHQEYEENLGDSIVGY). The present data indicate the characteristic existence of immunogenic regions in human TSH receptor for IgG of patients with Graves' disease. © 1990.
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页码：512 / 518
页数：7
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