CHIRAL SEPARATIONS BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY WITH SODIUM N-DODECANOYL-L-VALINATE

被引：124

作者：

OTSUKA, K ^{[1
]}

KAWAHARA, J ^{[1
]}

TATEKAWA, K ^{[1
]}

TERABE, S ^{[1
]}

机构：

[1] HIMEJI INST TECHNOL,FAC SCI,DEPT MAT SCI,KAMIGORI,HYOGO 67812,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 559卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(91)80071-N

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Chiral separations by micellar electrokinetic chromatography with sodium N-dodecanoyl-L-valinate (SDVal) were investigated. Addition of sodium dodecyl sulphate (SDS), urea and methanol to SDVal micellar solutions improved the peak shapes and resolution and also changed the selectivity. Phenylthiohydantoin (PTH) derivatives of six DL-amino acids (serine, alpha-aminobutyric acid, norvaline, valine, tryptophan and norleucine) were separated from each other and each pair of enantiomers was optically resolved with a 50 mM SDVal-30 mM SDS-0.5 M urea (pH 9.0)-10% (v/v) methanol solution. Some other enantiomers were also resolved.

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页码：209 / 214

页数：6

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