SIMULTANEOUS ESTIMATION OF DICLOFENAC SODIUM AND FAMOTIDINE BY REVERSED- PHASE THIN LAYER LIQUID CHROMATOGRAPHY / DENSITOMETRY METHOD IN BULK AND IN TABLET DOSAGE FORM

被引：2

作者：

Mhaske, Amol J. ^{[1
]}

Gawad, Jineetkumar B. ^{[1
]}

Patil, Vijay K. ^{[1
]}

机构：

[1] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Shirpur 425405, Maharashtra, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2013年 / 4卷 / 07期

关键词：

Famotidine; Diclofenac Sodium; Densitometry;

D O I：

10.13040/IJPSR.0975-8232.4(7).2677-82

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present work describes a validated reverse phase high performance thin layer liquid chromatographic method for simultaneous estimation of Diclofenac sodium and Famotidine in bulk and in pharmaceutical dosage form. Chromatographic separation of the drugs were performed on aluminum plates precoated with 200-mu m layers of silica gel 60 RP-18 F254S as the stationary phase and the solvent system consisted of methanol: water: triethylamine (7.5:3.5:0.5) (v/v/v). Densitometric evaluation of the separated zones was performed at 291 nm. The two drugs were satisfactorily resolved with R-f values 0.54 +/- 0.02 and 0.69 +/- 0.02 for Diclofenac Sodium and Famotidine, respectively. The accuracy and reliability of the method was assessed by evaluation of linearity over the range of 1500 ng/ band to 9000 ng/band for Diclofenac Sodium and over the range of 500 ng/ band to 3000ng/ band for Famotidine respectively.

引用

页码：2677 / 2682

页数：6

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