IDENTIFICATION OF MURINE LOCI ASSOCIATED WITH SUSCEPTIBILITY TO CHRONIC EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

被引：155

作者：

SUNDVALL, M

JIRHOLT, J

YANG, HT

JANSSON, L

ENGSTROM, A

PETTERSSON, U

HOLMDAHL, R

机构：

[1] LUND UNIV,DEPT MED INFLAMMAT RES,LUND,SWEDEN

[2] UNIV UPPSALA,DEPT MED & PHYSIOL CHEM,UPPSALA,SWEDEN

来源：

NATURE GENETICS | 1995年 / 10卷 / 03期

关键词：

D O I：

10.1038/ng0795-313

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

B10.RIII mice develop chronic and relapsing experimental autoimmune encephalomyelitis (EAE) after immunization with the myelin basic protein (MBP) peptide 89-101. The disease is associated with the major histocompatibility complex (MHC) (eae1). We have now investigated the importance of non-MHC regions for the EAE susceptibility in a cross between RIIIS/J and B10.RIII mice which share the MHC region but differ in disease susceptibility, Linkage analysis using microsatellite markers spanning the genome identified a region (eae2) on chromosome 15 which showed linkage to disease (P=0.0002). Our data also suggest linkage to a second region (eae3) on chromosome 3 (P=0.0024), and provide evidence for locus interactions between eae2 and eae3. These results provide clues to the genetic basis of multiple sclerosis.

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页码：313 / 317

页数：5

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