Design and Synthesis of Pyrazole-3-one Derivatives as Hypoglycaemic Agents

被引：40
作者：
Datar, Prasanna A. [1 ]
Jadhav, Sonali R. [1 ]
机构：
[1] Sinhgad Inst Pharm, Dept Pharmaceut Chem, Pune 411041, Maharashtra, India
来源：
INTERNATIONAL JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 2015卷
关键词：
D O I：
10.1155/2015/670181
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Pyrazole-3-one compounds were designed on the basis of docking studies of previously reported antidiabetic pyrazole compounds. The amino acid residues found during docking studies were used as guidelines for the modification of aromatic substitutions on pyrazole-3-one structure. Depending on the docking score, the designed compounds were selectively prioritized for synthesis. The synthesized compounds were subjected to in vivo hypoglycemic activity using alloxan induced diabetic rats and metformin as a standard. Compound 4 having sulphonamide derivative was found to be the most potent compound among the series.
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页数：10
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