CATALYTIC ENANTIOSELECTIVE MACROLIDE SYNTHESIS .2. USE OF DIFFERENTIAL DEPROTECTION PROTOCOLS

被引：24

作者：

JONES, GB

CHAPMAN, BJ

HUBER, RS

BEATY, R

机构：

[1] Department of Chemistry, Clemson University, Clemson

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 07期

关键词：

D O I：

10.1016/0957-4166(94)80156-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Catalytic enantioselective synthesis of Phorcantholide I has been achieved. Key stereochemistry was introduced using a chiral arene chromium tricarbonyl based catalyst to mediate the addition of dimethyl zinc to a functionalised aldehyde. During the synthesis, a method for the Selective deprotection of the trityloxy group was revealed and developed.

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页码：1199 / 1202

页数：4

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