INHIBITION BY L-GLUTAMINE OF THE RELEASE OF ENDOTHELIUM-DERIVED RELAXING FACTOR FROM CULTURED ENDOTHELIAL-CELLS

被引:44
作者
HECKER, M
MITCHELL, JA
SWIERKOSZ, TA
SESSA, WC
VANE, JR
机构
[1] William Harvey Research Inst., St. Bartholomew's Hospital, Medical College
关键词
D O I
10.1111/j.1476-5381.1990.tb12693.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
L-Glutamine (0.02-2 mM) but not D-glutamine (0.2 mM and 2 mM) inhibited the release of endothelium-derived relaxing factor (EDRF) from bovine aortic endothelial cells cultured in the presence or absence of L-arginine. Inhibition was maximal at a concentration of 200 μM, and was reversed by L-arginine (50 μM) but not D-arginine (100 μM). L-Glutamic acid (2 mM) or ammonium chloride (1 mM), putative products of the metabolism of L-glutamine in endothelial cells, had no effect on EDRF release. L-Glutamine (0.2 mM and 2 mM) but not D-glutamine (2 mM), L-glutamic acid (2 mM) or ammonium chloride (1 mM) also inhibited the generation of L-arginine in endothelial cells. Thus, L-glutamine inhibits EDRF release by preventing the generation of L-arginine.
引用
收藏
页码:237 / 239
页数:3
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