A CONVENIENT ASYMMETRIC-SYNTHESIS OF THALIDOMIDE

被引：38

作者：

ROBIN, S

ZHU, J

GALONS, H

PHAMHUY, C

CLAUDE, JR

TOMAS, A

VIOSSAT, B

机构：

[1] FAC PHARM PARIS,CHIM ORGAN LAB,F-75270 PARIS,FRANCE

[2] FAC PHARM PARIS,TOXICOL LAB,F-75270 PARIS,FRANCE

[3] FAC PHARM PARIS,PHYS LAB,F-75270 PARIS,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 06期

关键词：

D O I：

10.1016/0957-4166(95)00155-I

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Benzyloxyamine reacted with BOC-glutamic-alpha-phenyl ester in the presence of carbodiimide to give BOC-amino-N-benzyloxypiperidinedione. Deprotection of the amino group followed by phthaloylation led to N-benzyloxythalidomide which was then converted into thalidomide.

引用

页码：1249 / 1252

页数：4

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