LAMBERT-EATON MYASTHENIC SYNDROME AND POLYNEUROPATHY IN A PATIENT WITH EPIDERMOID CARCINOMA OF THE LUNG

被引：5
|
作者：
COMOLA, M
NEMNI, R
SHER, E
QUATTRINI, A
FARAVELLI, A
COMI, G
CORBO, M
CLEMENTI, F
CANAL, N
机构：
[1] UNIV MILAN,IRCCS H SAN RAFFAELE,DEPT SURG PATHOL,I-20132 MILAN,ITALY
[2] UNIV MILAN,DEPT MED PHARMACOL,CNR,CTR CYTOPHARMACOL,I-20122 MILAN,ITALY
来源：
EUROPEAN NEUROLOGY | 1993年 / 33卷 / 02期
关键词：
MYASTHENIC SYNDROME; PERIPHERAL NEUROPATHY; EPIDERMOID CARCINOMA; CALCIUM CHANNELS; AUTOANTIBODIES;
D O I：
10.1159/000116917
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We describe a patient affected by the Lambert-Eaton myasthenic syndrome, sensory motor axonal neuropathy and epidermoid carcinoma of the lung. Serum autoantibodies to voltage-operated calcium channels were detected. After lobectomy, voltage-operated calcium channel-related structures were demonstrated in the patient's tumor. By immunocytochemistry, the patient's IgG reacted with neural structures and particularly with intermediate filaments. We think that these autoantibodies may be implicated in the pathogenesis of the neurological symptomatology.
引用
收藏
页码：121 / 125
页数：5
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