LAMBERT-EATON MYASTHENIC SYNDROME AND POLYNEUROPATHY IN A PATIENT WITH EPIDERMOID CARCINOMA OF THE LUNG

被引：5
|
作者：
COMOLA, M
NEMNI, R
SHER, E
QUATTRINI, A
FARAVELLI, A
COMI, G
CORBO, M
CLEMENTI, F
CANAL, N
机构：
[1] UNIV MILAN,IRCCS H SAN RAFFAELE,DEPT SURG PATHOL,I-20132 MILAN,ITALY
[2] UNIV MILAN,DEPT MED PHARMACOL,CNR,CTR CYTOPHARMACOL,I-20122 MILAN,ITALY
来源：
EUROPEAN NEUROLOGY | 1993年 / 33卷 / 02期
关键词：
MYASTHENIC SYNDROME; PERIPHERAL NEUROPATHY; EPIDERMOID CARCINOMA; CALCIUM CHANNELS; AUTOANTIBODIES;
D O I：
10.1159/000116917
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We describe a patient affected by the Lambert-Eaton myasthenic syndrome, sensory motor axonal neuropathy and epidermoid carcinoma of the lung. Serum autoantibodies to voltage-operated calcium channels were detected. After lobectomy, voltage-operated calcium channel-related structures were demonstrated in the patient's tumor. By immunocytochemistry, the patient's IgG reacted with neural structures and particularly with intermediate filaments. We think that these autoantibodies may be implicated in the pathogenesis of the neurological symptomatology.
引用
收藏
页码：121 / 125
页数：5
相关论文
共 48 条
  • [11] Update in the Management of Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome
    Bodkin, Cynthia
    Pascuzzi, Robert M.
    NEUROLOGIC CLINICS, 2021, 39 (01) : 133 - 146
  • [12] Italian recommendations for Lambert-Eaton myasthenic syndrome (LEMS) management
    Evoli, A.
    Liguori, R.
    Romani, A.
    Mantegazza, R.
    Di Muzio, A.
    Giometto, B.
    Pegoraro, E.
    Rodolico, C.
    Vigliani, M. C.
    NEUROLOGICAL SCIENCES, 2014, 35 (04) : 515 - 520
  • [13] Idiopathic Lambert-Eaton myasthenic syndrome.: Report of one case
    Guevara, C
    Pedraza, L
    Idiáquez, J
    Delgado, M
    REVISTA MEDICA DE CHILE, 2006, 134 (02) : 217 - 222
  • [14] Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome: New Developments in Diagnosis and Treatment
    Pascuzzi, Robert
    Bodkin, Cynthia
    NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2022, 18 : 3001 - 3022
  • [15] 3,4-Diaminopyridine (amifampridine) for the treatment of Lambert-Eaton myasthenic syndrome
    Lindquist, Sabine
    Stangel, Martin
    EXPERT OPINION ON ORPHAN DRUGS, 2014, 2 (03): : 293 - 300
  • [16] Successful treatment of advanced lung adenocarcinoma complicated with Lambert-Eaton myasthenic syndrome: A case report and literature review
    Wang, Aili
    Zhang, Xin
    Yi, Jiawen
    Zhu, Min
    Zhang, Yuhui
    THORACIC CANCER, 2020, 11 (05) : 1334 - 1338
  • [17] Neuromuscular Active Zone Structure and Function in Healthy and Lambert-Eaton Myasthenic Syndrome States
    Ginebaugh, Scott P.
    Badawi, Yomna
    Tarr, Tyler B.
    Meriney, Stephen D.
    BIOMOLECULES, 2022, 12 (06)
  • [18] ANTIBODIES TO RECOMBINANT SYNAPTOTAGMIN AND CALCIUM-CHANNEL SUBTYPES IN LAMBERT-EATON MYASTHENIC SYNDROME
    TAKAMORI, M
    TAKAHASHI, M
    YASUKAWA, Y
    IWASA, K
    NEMOTO, Y
    SUENAGA, A
    NAGATAKI, S
    NAKAMURA, T
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 1995, 133 (1-2) : 95 - 101
  • [19] Lambert-Eaton myasthenic syndrome - Recent developments, diagnostic methods and case report of a patient with concomitant myasthenia gravis
    Spalek, P
    Brozman, B
    Lisy, L
    Vincent, A
    CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE, 1999, 62 (03) : 163 - 166
  • [20] FAVORABLE RESPONSE TO RITUXIMAB IN A PATIENT WITH ANTI-VGCC-POSITIVE LAMBERT-EATON MYASTHENIC SYNDROME AND CEREBELLAR DYSFUNCTION
    Pellkofer, Hannah L.
    Voltz, Raymond
    Kuempfel, Tania
    MUSCLE & NERVE, 2009, 40 (02) : 305 - 308
12345