SQUAMOUS-CELL CARCINOMA ANTIGEN IS A POTENT INHIBITOR OF CYSTEINE PROTEINASE CATHEPSIN-L

被引：58

作者：

TAKEDA, A ^{[1
]}

YAMAMOTO, T ^{[1
]}

NAKAMURA, Y ^{[1
]}

TAKAHASHI, T ^{[1
]}

HIBINO, T ^{[1
]}

机构：

[1] SHISEIDO RES CTR, KANAZAWA KU, YOKOHAMA, KANAGAWA 227, JAPAN

来源：

FEBS LETTERS | 1995年 / 359卷 / 01期

关键词：

SQUAMOUS CELL CARCINOMA ANTIGEN (SCCA); SERPIN; PROTEINASE INHIBITOR; CATHEPSIN L;

D O I：

10.1016/0014-5793(94)01456-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A squamous cell carcinoma antigen (SSCA), which is a member of the serpin family of proteinase inhibitors, was purified from sera of cancer patients. It did not inhibit serine proteinases. However, it non-competitively inhibited human cathepsin L with a K-i of 0.064 nM, but not cathepsins B and H among cysteine proteinases. These results indicated that SCCA is a non-functional serpin that inhibits cathepsin L in cancer cells.

引用

页码：78 / 80

页数：3