SQUAMOUS-CELL CARCINOMA ANTIGEN IS A POTENT INHIBITOR OF CYSTEINE PROTEINASE CATHEPSIN-L

被引：58

作者：

TAKEDA, A ^{[1
]}

YAMAMOTO, T ^{[1
]}

NAKAMURA, Y ^{[1
]}

TAKAHASHI, T ^{[1
]}

HIBINO, T ^{[1
]}

机构：

[1] SHISEIDO RES CTR, KANAZAWA KU, YOKOHAMA, KANAGAWA 227, JAPAN

来源：

FEBS LETTERS | 1995年 / 359卷 / 01期

关键词：

SQUAMOUS CELL CARCINOMA ANTIGEN (SCCA); SERPIN; PROTEINASE INHIBITOR; CATHEPSIN L;

D O I：

10.1016/0014-5793(94)01456-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A squamous cell carcinoma antigen (SSCA), which is a member of the serpin family of proteinase inhibitors, was purified from sera of cancer patients. It did not inhibit serine proteinases. However, it non-competitively inhibited human cathepsin L with a K-i of 0.064 nM, but not cathepsins B and H among cysteine proteinases. These results indicated that SCCA is a non-functional serpin that inhibits cathepsin L in cancer cells.

引用

页码：78 / 80

页数：3

共 32 条

[1]

BARRETT AJ, 1986, RES MONOG CELL TISSU, V12, P515

[2] NATURAL PROTEIN PROTEINASE-INHIBITORS AND THEIR INTERACTION WITH PROTEINASES [J].

BODE, W ;

HUBER, R .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 204 (02) :433-451

[3]

CHAUHAN SS, 1991, CANCER RES, V51, P1478

[4]

CROMBACH G, 1989, CANCER, V63, P1337, DOI 10.1002/1097-0142(19890401)63:7<1337::AID-CNCR2820630719>3.0.CO

[5]

2-J

[6]

DANO K, 1993, PORTL PR P, P239

[7] THE DETERMINATION OF ENZYME INHIBITOR CONSTANTS [J].

DIXON, M .

BIOCHEMICAL JOURNAL, 1953, 55 (01) :170-171

[8]

DUK JM, 1989, CANCER, V64, P1652, DOI 10.1002/1097-0142(19891015)64:8<1652::AID-CNCR2820640816>3.0.CO

[9]

2-M

[10]

GOTTESMAN MM, 1993, PORTL PR P, P247

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