LEVOCABASTINE EYE DROPS ARE EFFECTIVE AND WELL TOLERATED FOR THE TREATMENT OF ALLERGIC CONJUNCTIVITIS IN CHILDREN

被引:3
|
作者
WUTHRICH, B
GERBER, M
机构
[1] UNIV ZURICH HOSP,DEPT DERMATOL,ALLERGY UNIT,CH-8091 ZURICH,SWITZERLAND
[2] JANSSEN RES FDN,CH-6341 BAARN,SWITZERLAND
关键词
ALLERGIC CONJUNCTIVITIS; CHILDREN; H-1-RECEPTOR ANTAGONIST; LEVOCABASTINE; TOPICAL ANTIHISTAMINE;
D O I
10.1155/S0962935195000792
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
THIS open-label, prospective, multicentre, 4-week trial was undertaken to assess the efficacy and tolerability of twice daily levocabastine eye drops (0.5 mg/ml), with sodium cromoglycate nasal spray for the relief of concurrent nasal symptoms if required, in a total of 233 children with seasonal allergic conjunctivitis. No correlation between efficacy, tolerability and age was found Investigator assessments revealed that the total severity of ocular symptoms decreased by 84 +/- 34% in patients < 12 years and 85 +/- 30% in those greater than or equal to 12 years, with corresponding reductions in the total severity of ocular findings of 84% in both patient groups over the 4-week treatment period Global assessments of therapeutic efficacy revealed the effect of therapy on ocular symptoms to be excellent or good in 81% of patients < 12 years and 82% of those greater than or equal to 12 years after 2 weeks of treatment, with corresponding values at the end of the trial of 88% and 82% in the two groups, respectively. Treatment tolerability was considered to be excellent or good by 94% of patients overall. Application site reactions were the most common adverse event associated with ocular levocabastine, occurring in 13% of patients < 12 years and 9% of those greater than or equal to 12 years. Twice daily levocabastine eye drops therefore appear to be effective and well tolerated for the treatment of seasonal allergic conjunctivitis in children.
引用
收藏
页码:S16 / S20
页数:5
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