NADPH ACTIVATES A DECARBOXYLATION REACTION CATALYZED BY LAMB LIVER 6-PHOSPHOGLUCONATE DEHYDROGENASE

被引：23
|
作者：
HANAU, S [1 ]
DALLOCCHIO, F [1 ]
RIPPA, M [1 ]
机构：
[1] UNIV FERRARA,IST CHIM BIOL,VIA LUIGI BORSARI 46,I-44100 FERRARA,ITALY
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1122卷 / 03期
关键词：
PHOSPHOGLUCONATE DEHYDROGENASE; OXIDATIVE DECARBOXYLATION; ENZYME MECHANISM; PHOSPHODEOXYGLUCONATE; (LAMB LIVER);
D O I：
10.1016/0167-4838(92)90404-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
NADP-dependent lamb liver 6-phosphogluconate deydrogenase catalyses the oxidative decarboxylation of 2-deoxy-6-phospho-gluconate, an analogue of the natural substrate. The first products of the reaction are NADPH and 3-keto-2-deoxy-6-phospho-gluconate. The NADPH, released from the enzyme, binds to the coenzyme site of the same or the other subunit, activating the decarboxylation reaction in which has not a redox role, since it can be substituted by an analogue devoid of enzymatic redox power. These findings are compared to those obtained with other NADP-dependent decarboxylating dehydrogenases.
引用
收藏
页码：273 / 277
页数：5
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