IDENTIFICATION OF A NOVEL NUCLEOSIDE, 1,N-6-DIMETHYLADENOSINE, IN HUMAN CANCER URINE

被引：7

作者：

HAMMARGREN, WM ^{[1
]}

SCHRAM, KH ^{[1
]}

NAKANO, K ^{[1
]}

YASAKA, T ^{[1
]}

机构：

[1] PL COMPREHENS RES INST, TONDABAYASHI, OSAKA 584, JAPAN

来源：

ANALYTICA CHIMICA ACTA | 1991年 / 247卷 / 02期

基金：

美国国家卫生研究院;

关键词：

GAS CHROMATOGRAPHY; MASS SPECTROMETRY; DIMETHYLADENOSINE; URINE;

D O I：

10.1016/S0003-2670(00)83814-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The identification of 1,N6-dimethyladenosine in the urine of a lung cancer patient is reported. Prior to the characterization of the trimethylsilyl derivative by gas chromatography-mass spectrometry, the separation and partial purification of the compound was accomplished by a boronate gel affinity technique followed by reversed-phase high-performance liquid chromatography. The structure was confirmed by comparison of the mass spectral and chromatographic features of the urinary component to those of a synthetic standard.

引用

页码：201 / 209

页数：9

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