PLATINATION PATHWAYS FOR REACTIONS OF CISPLATIN WITH GG SINGLE-STRANDED AND DOUBLE-STRANDED DECANUCLEOTIDES

被引：54

作者：

BARNHAM, KJ

BERNERSPRICE, SJ

FRENKIEL, TA

FREY, U

SADLER, PJ

机构：

[1] GRIFFITH UNIV,FAC SCI & TECHNOL,NATHAN,QLD 4111,AUSTRALIA

[2] NATL INST MED RES,CTR BIOMED NMR,LONDON NW7 1AA,ENGLAND

[3] UNIV LAUSANNE,INST CHIM MINERALE & ANALYT,CH-1015 LAUSANNE,SWITZERLAND

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 17期

关键词：

ANTITUMOR AGENTS; DNA; NMR SPECTROSCOPY; NUCLEOTIDES; PLATINUM COMPOUNDS;

D O I：

10.1002/anie.199518741

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1H, 15N correlated NMR spectroscopy has proven to be a suitable method to investigate the reaction of the anticancer drug cisplatin cis‐[PtCl2(NH3)2] (1) with DNA. All the intermediates in reactions of 1 with complementary model oligonucleotides can be detected with this method; one of these intermediates is shown. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

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页码：1874 / 1877

页数：4

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