Anticoagulation for Atrial Fibrillation: New Oral Anticoagulants?

被引：0

作者：

Omran, H. ^{[1
]}

von der Recke, G.

机构：

[1] St Josef Hosp Bonn Beuel, St Marien Hosp Bonn Venusberg, Innere Abt, Bonn, Germany

来源：

AKTUELLE KARDIOLOGIE | 2012年 / 1卷 / 03期

关键词：

new oral anticoagulants; atrial fibrillation; Apixaban; Dabigatran; Rivaroxaban;

D O I：

10.1055/s-0032-1315031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dabigatran and rivaroxaban are 2 newly licensed oral anticoagulants for the treatment of atrial fibrillation. It is expected that apixaban will also soon be approved for clinical use. All of these substances have a more favorable pharmacological profile than vitamin K antagonists. They generally do not require routine laboratory monitoring and are safer. The new oral anticoagulants were found to reduce rates of intracranial bleeding. Both dabigatran and apixaban significantly reduced the incidence of stroke. Dabigatran administered at a dosage of 2 x 150 mg reduced the rates of ischemic stroke, while apixaban reduced overall mortality. Rivaroxaban has the advantage that it is administered as a single dose and can be administered up to a CrCl of 15ml/min.

引用

页码：192 / 198

页数：7

共 24 条

[1] Use and effectiveness of warfarin in medicare beneficiaries with atrial fibrillation [J].

Birman-Deych, E ;

Radford, MJ ;

Nilasena, DS ;

Gage, BF .

STROKE, 2006, 37 (04) :1070-1074

[2] Benefit of Oral Anticoagulant Over Antiplatelet Therapy in Atrial Fibrillation Depends on the Quality of International Normalized Ratio Control Achieved by Centers and Countries as Measured by Time in Therapeutic Range [J].

Connolly, Stuart J. ;

Pogue, Janice ;

Eikelboom, John ;

Flaker, Gregory ;

Commerford, Patrick ;

Franzosi, Maria Grazia ;

Healey, Jeffrey S. ;

Yusuf, Salim .

CIRCULATION, 2008, 118 (20) :2029-2037

[3] Apixaban in Patients with Atrial Fibrillation [J].

Connolly, Stuart J. ;

Eikelboom, John ;

Joyner, Campbell ;

Diener, Hans-Christoph ;

Hart, Robert ;

Golitsyn, Sergey ;

Flaker, Greg ;

Avezum, Alvaro ;

Hohnloser, Stefan H. ;

Diaz, Rafael ;

Talajic, Mario ;

Zhu, Jun ;

Pais, Prem ;

Budaj, Andrzej ;

Parkhomenko, Alexander ;

Jansky, Petr ;

Commerford, Patrick ;

Tan, Ru San ;

Sim, Kui-Hian ;

Lewis, Basil S. ;

Van Mieghem, Walter ;

Lip, Gregory Y. H. ;

Kim, Jae Hyung ;

Lanas-Zanetti, Fernando ;

Gonzalez-Hermosillo, Antonio ;

Dans, Antonio L. ;

Munawar, Muhammad ;

O'Donnell, Martin ;

Lawrence, John ;

Lewis, Gayle ;

Afzal, Rizwan ;

Yusuf, Salim .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (09) :806-817

[4] Dabigatran versus Warfarin in Patients with Atrial Fibrillation. [J].

Connolly, Stuart J. ;

Ezekowitz, Michael D. ;

Yusuf, Salim ;

Eikelboom, John ;

Oldgren, Jonas ;

Parekh, Amit ;

Pogue, Janice ;

Reilly, Paul A. ;

Themeles, Ellison ;

Varrone, Jeanne ;

Wang, Susan ;

Alings, Marco ;

Xavier, Denis ;

Zhu, Jun ;

Diaz, Rafael ;

Lewis, Basil S. ;

Darius, Harald ;

Diener, Hans-Christoph ;

Joyner, Campbell D. ;

Wallentin, Lars .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (12) :1139-1151

[5] New Oral Anticoagulants in Atrial Fibrillation and Acute Coronary Syndromes ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease Position Paper [J].

De Caterina, Raffaele ;

Husted, Steen ;

Wallentin, Lars ;

Andreotti, Felicita ;

Arnesen, Harald ;

Bachmann, Fedor ;

Baigent, Colin ;

Huber, Kurt ;

Jespersen, Jorgen ;

Kristensen, Steen Dalby ;

Lip, Gregory Y. H. ;

Morais, Joao ;

Rasmussen, Lars Hvilsted ;

Siegbahn, Agneta ;

Verheugt, Freek W. A. ;

Weitz, Jeffrey I. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (16) :1413-1425

[6] Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate A Randomized, Placebo-Controlled, Crossover Study in Healthy Subjects [J].

Eerenberg, Elise S. ;

Kamphuisen, Pieter W. ;

Sijpkens, Meertien K. ;

Meijers, Joost C. ;

Buller, Harry R. ;

Levi, Marcel .

CIRCULATION, 2011, 124 (14) :1573-1579

[7] Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment [J].

Fox, Keith A. A. ;

Piccini, Jonathan P. ;

Wojdyla, Daniel ;

Becker, Richard C. ;

Halperin, Jonathan L. ;

Nessel, Christopher C. ;

Paolini, John F. ;

Hankey, Graeme J. ;

Mahaffey, Kenneth W. ;

Patel, Manesh R. ;

Singer, Daniel E. ;

Califf, Robert M. .

EUROPEAN HEART JOURNAL, 2011, 32 (19) :2387-2394

[8] ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation:: full text [J].

Fuster, Valentin ;

Ryden, Lars E. ;

Cannom, David S. ;

Crijns, Harry J. ;

Curtis, Anne B. ;

Ellenbogen, Kenneth A. ;

Halperin, Jonathan L. ;

Le Heuzey, Jean-Yves ;

Kay, G. Neal ;

Lowe, James E. ;

Olsson, S. Bertil ;

Prystowsky, Eric N. ;

Tamargo, Juan Luis ;

Wann, Samuel .

EUROPACE, 2006, 8 (09) :651-745

[9] Apixaban versus Warfarin in Patients with Atrial Fibrillation [J].

Granger, Christopher B. ;

Alexander, John H. ;

McMurray, John J. V. ;

Lopes, Renato D. ;

Hylek, Elaine M. ;

Hanna, Michael ;

Al-Khalidi, Hussein R. ;

Ansell, Jack ;

Atar, Dan ;

Avezum, Alvaro ;

Cecilia Bahit, M. ;

Diaz, Rafael ;

Easton, J. Donald ;

Ezekowitz, Justin A. ;

Flaker, Greg ;

Garcia, David ;

Geraldes, Margarida ;

Gersh, Bernard J. ;

Golitsyn, Sergey ;

Goto, Shinya ;

Hermosillo, Antonio G. ;

Hohnloser, Stefan H. ;

Horowitz, John ;

Mohan, Puneet ;

Jansky, Petr ;

Lewis, Basil S. ;

Luis Lopez-Sendon, Jose ;

Pais, Prem ;

Parkhomenko, Alexander ;

Verheugt, Freek W. A. ;

Zhu, Jun ;

Wallentin, Lars .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (11) :981-992

[10] Meta-analysis: Antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation [J].

Hart, Robert G. ;

Pearce, Lesly A. ;

Aguilar, Maria I. .

ANNALS OF INTERNAL MEDICINE, 2007, 146 (12) :857-867

← 1 2 3 →