RECOVERY OF RESPONSE TO ADRIAMYCIN AND CYCLOPHOSPHAMIDE BY LONIDAMINE IN PREVIOUSLY TREATED METASTATIC BREAST-CANCER PATIENTS

被引：0

作者：

TOMIROTTI, M

BERNARDO, G

EPIFANI, C

BIASIOLI, R

FRANCHI, R

MENSI, F

CARNAGHI, P

SCHIEPPATI, G

SCANNI, A

机构：

[1] FDN CLIN LAVORO,PAVIA,ITALY

[2] OSPED COMO,COMO,ITALY

[3] OSPED MAGENTA,MAGENTA,ITALY

[4] OSPED CODOGNO,CODOGNO,ITALY

[5] OSPED MELEGNANO,MELEGNANO,ITALY

[6] OSPED CASTELLANZA,CASTELLANZA,ITALY

[7] OSPED SARONNO,SARONNO,ITALY

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 1993年 / 3卷 / 02期

关键词：

LONIDAMINE; METASTATIC BREAST CANCER; RECOVERY OF RESPONSE; REVERSAL OF MULTIDRUG RESISTANCE; ADRIAMYCIN; CYCLOPHOSPHAMIDE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thirty-one patients with metastatic breast cancer not responding or progressing after initial response to adriamycin + cyclophosphamide (AC) treatment entered a phase 11 study with oral lonidamine in association to AC. Objective clinical responses were observed in 10 patients (32%) and consisted of 1 complete + 9 partial remissions. Disease stability and progression were observed in 8 and 13 cases, respectively. These results were obtained with a marginal toxicity in addition to that already reported for AC therapy, the main additional side effect being myalgia, which was easily manageable in most cases.

引用

页码：213 / 217

页数：5

共 29 条

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