EFFECT OF DIETARY MAGNESIUM SUPPLEMENTATION ON INTRALYMPHOCYTIC FREE CALCIUM AND MAGNESIUM IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS

被引：23

作者：

ADACHI, M ^{[1
]}

NARA, Y ^{[1
]}

MANO, M ^{[1
]}

YAMORI, Y ^{[1
]}

机构：

[1] KYOTO UNIV,GRAD SCH HUMAN & ENVIRONM STUDIES,KYOTO 606,JAPAN

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 1994年 / 16卷 / 03期

关键词：

DIETARY MAGNESIUM; INTRALYMPHOCYTIC FREE CALCIUM; INTRALYMPHOCYTIC FREE MAGNESIUM; STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS;

D O I：

10.3109/10641969409072219

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of dietary magnesium (Mg) supplementation on intralymphocytic free Ca2+ ([Ca2+]i) and Mg2+ ([Mg2+]i) were examined in the stroke-prone spontaneously hypertensive rats (SHRSP) at the age of 10 weeks. After 40 day Mg supplementation (0.8% Mg in the diet), systolic blood pressure (SBP) was significantly lower in Mg supplemented group (Mg group) than the control group (0.2% Mg). [Ca2+]i was significantly lower and [Mg2+]i was significantly higher in Mg group than in the control group. Further, [Ca2+]i was positively and [Mg2+]i was negatively correlated with SBP. These results suggest that dietary Mg supplementation modifies [Ca2+]i and [Mg2+]i, and modulates the development of hypertension.

引用

页码：317 / 326

页数：10

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