INHIBITORY EFFECT OF TETRAHYDROBERBERINE ON PLATELET-AGGREGATION AND THROMBOSIS

被引：0

作者：

XUAN, B ^{[1
]}

WANG, W ^{[1
]}

LI, DX ^{[1
]}

机构：

[1] NANJING MED COLL,DEPT PATHOL,NANJING 210029,PEOPLES R CHINA

来源：

ACTA PHARMACOLOGICA SINICA | 1994年 / 15卷 / 02期

关键词：

BERBERINES; PLATELET AGGREGATION; THROMBOXANE B-2; THROMBOSIS; ASPIRIN; ARACHIDONIC ACID; ADENOSINE DIPHOSPHATE; COLLAGEN;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tetrahydroberberine (THB), an alkaloid extracted from Corydalis ambigua, inhibited the rabbit platelet aggregation triggered by arachidonic acid (AA), ADP, and collagen with IC50 of 0.86, 1.31, and 1.10 mmol.L(-1), respectively. THB reduced the thromboxane B-2(TXB(2)) generation in rabbit platelet-rich plasma triggered by AA THB 30 mg.kg(-1).d(-1) ip for 3 or 5 d restrained the ADP-induced platelet aggregation in rats. THB 30 mg.kg(-1).d(-1) ip for 1, 3, or 5 d inhibited the AA-induced platelet aggregation in rats. THB 15-30 mg.kg(-1) iv showed an inhibition of venous thrombosis in rats. The results show that THB is a patent inhibitor of platelet aggregation in vitro and in vivo and is a promising antithrombotic drug.

引用

页码：133 / 135

页数：3