PROKARYOTIC MEMBERS OF A NEW FAMILY OF PUTATIVE HELICASES WITH SIMILARITY TO TRANSCRIPTION ACTIVATOR SNF2

被引：22

作者：

KOLSTO, AB

BORK, P

KVALOY, K

LINDBACK, T

GRONSTADT, A

KRISTENSEN, T

SANDER, C

机构：

[1] UNIV OSLO, CTR BIOTECHNOL, N-0137 OSLO 3, NORWAY

[2] EUROPEAN MOLEC BIOL LAB, W-6900 HEIDELBERG, GERMANY

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1993年 / 230卷 / 02期

关键词：

HOMOLOGY; HELICASES; SNF2; FAMILY; BACILLUS-CEREUS; TRANSCRIPTION REGULATION;

D O I：

10.1006/jmbi.1993.1185

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cloning and sequence analysis of a new open reading frame from Bacillus cereus reveals the relationship to a recently identified family of putative eukaryotic transcription activators similar to the yeast SNF2 gene product. As a result of comparative analysis of sequence features conserved in all members of this family, a gene from a chilo iridescent virus, as well as a putative helicase from Escherichia coli (hepA), can also be grouped into this family. The unexpected presence of prokaryotic and viral sequences in the previously purely eukaryotic SNF2 family suggests a defined subgroup of DNA helicases present in all species, with specific function in transcription activation. © 1993 Academic Press, Inc.

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页码：684 / 688

页数：5

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