A PROSPECTIVE, RANDOMIZED STUDY USING ULINASTATIN FOR THE TREATMENT OF PATIENTS WITH SEVERE SEPSIS

被引：2

作者：

Bashir, Farhana ^{[1
]}

Rather, Mushtaq Ahmad ^{[1
]}

Saleem, Basharat ^{[1
]}

Hamid, Abdul ^{[1
]}

机构：

[1] Govt Medial Coll, Dept Anaesthesia & Intens Care, Srinagar, Jammu & Kashmir, India

来源：

JOURNAL OF EVOLUTION OF MEDICAL AND DENTAL SCIENCES-JEMDS | 2014年 / 3卷 / 53期

关键词：

Ulinastatin; Severe sepsis; Organ failure scores;

D O I：

10.14260/jemds/2014/3618

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A prospective, randomized study was conducted on patients of severe sepsis using ulinastatin for treatment. Total of 50 patients were taken up for this study who were randomly assigned in two groups: 25 patients in group A who were given ulinastatin and 25 patients in group B who were given placebo. Patients were evaluated clinically using Acute physiology and chronic health evaluation(APACHE), Multiple organ failure (MOF) and Glasgow coma score (GCS), at the time of admission and after therapy on the 3rd, 8th and 28th day. RESULTS: There was a significant difference between the two groups regarding the organ failure scores. Patients in group A showed a better performance in APACHE II, MOF and GCS as compared to patients in group B on 3rd, 8th and 28th day of admission. CONCLUSION: Ulinastatin has a beneficial role in the treatment of patients with severe sepsis.

引用

页码：12241 / 12246

页数：6

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